Collectively, our results may provide a novel understanding of the interaction between artificial sweeteners and the gut microbiome, as well as the potential role of this interaction in the development of obesity and the associated chronic inflammation.Īs widely used food additives and sugar substitutes, artificial sweeteners can enhance flavor and simultaneously reduce calorie intake. In particular, ace-K increased body weight gain of male but not female mice. The observed body weight gain, shifts in the gut bacterial community composition, enrichment of functional bacterial genes related to energy metabolism, and fecal metabolomic changes were highly gender-specific, with differential effects observed for males and females. We found that Ace-K consumption perturbed the gut microbiome of CD-1 mice after a 4-week treatment. In this study, we explored the effects of Ace-K on the gut microbiome and the changes in fecal metabolic profiles using 16S rRNA sequencing and gas chromatography-mass spectrometry (GC-MS) metabolomics. In particular, the functional impact of Ace-K on the gut microbiome is largely unknown. Acesulfame-potassium (Ace-K), a FDA-approved artificial sweetener, is commonly used, but its toxicity data reported to date are considered inadequate. Interestingly, the artificial sweetener saccharin could alter gut microbiota and induce glucose intolerance, raising questions about the contribution of artificial sweeteners to the global epidemic of obesity and diabetes. Numerous studies have indicated an important role of the gut microbiome in body weight control and glucose metabolism and regulation. and other countries over the last two decades.
Obesity and type 2 diabetes have dramatically increased in the U.S.
Artificial sweeteners have been widely used in the modern diet, and their observed effects on human health have been inconsistent, with both beneficial and adverse outcomes reported.
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